Possible Interaction: Chloretone and Vitamin C

“It will be noted that Chloretone within the first day exerts an effect on ascorbic acid excretion that reaches a peak by the third day and falls to a low value by the fifth day.”

“ Vitamin C synthesis in rat liver is enhanced by several xenobiotics, including aminopyrine and chloretone.”

“It is well known that the administration of chloretone , phenobarbital or methylcholanthrene induces an increase in the urinary excretion of ascorbic acid and they also induce an increase in the activities of drug-metabolizing enzyme of liver microsomes (1-3).”

“Other types of compounds, such as chloretone , aminopyrine, meprobamate and phenylbutazone, also increase the urinary excretion of ascorbic acid in rats2,3.”

“The synthesis of ascorbic acid as reflected in the urinary excretion and tissue reserve of rats can be greatly stimulated by chloretone and completely suppressed by the simultaneous administration of ATP, malic acid, or thyroxine to the treated animals.”

“Furthermore, the information would furnish a better understanding of the manner by which various organic compounds, particularly drugs such as Chloretone , paraldehyde, and barbiturates, markedly increase the urinary excretion of ascorbic acid (4).”

“… Chloretone’ , barbital, … L-ascorbic acid from glucose through the glucuronic acid pathway1–3 as follows: Evidence for this has come from the observations that these drugs markedly … that they stimulate the conversion of glucose-1-14C to labelled D-glucuronic acid, L-gulonic acid and L-ascorbic acid3–5.”