Possible Interaction: Chlordiazepoxide and Gamma-Aminobutyric Acid

“It is concluded that chlordiazepoxide may enhance GABA transmission within the substantia nigra, by some as yet unidentified mechanism, to create asymmetric activity in GABA-modulated neurones and hence induce rotation.”

“Imax values for piperidine‐4‐sulphonic acid P4S ) on α1β3γ2, THIP on α3β3γ2, and 5‐(4‐piperidyl)isothiazol‐3‐ol (thio‐4‐PIOL) on α2β3γ2 and α5β3γ2 GABAA receptors were increased by chlordiazepoxide , while that for P4S on α1β3γ2 receptors was decreased by DMCM.”

“ResultsKetamine appeared to impair perceptual grouping in this paradigm, while the GABA agonist chlordiazepoxide enhanced grouping even in the presence of non-selective effects.”

“Finally, that EOS alone did not mimic the effects of CDP suggests that the role of GABA in the anxiolytic action of CDP may be indirect.”

“ Chlordiazepoxide increased the effect of exogenous GABA which by inhibiting basal release of alpha-MSH demonstrated that the tonic inhibition was not maximal in the resting state.”

“The chronic administration of chlordiazepoxide significantly modified the activity of both activators (strychnine, metrazol, bicuculline, picrotoxin) and inhibitors ( GABA , chlordiazepoxide) of the spontaneous motility of chick embryos.”

“Both GABA and CDP injected into the amygdala selectively increased conflict rates, but with peripheral treatment CDP also increased TO rates.”

“These results provide evidence that both increased GABA and decreased serotonin transmission are involved in the anticonflict effects of CDP , as EOS and PCPA both mimicked and potentiated effects of CDP, while picrotoxin, Wy 25093, and 5-HTP counteracted them.(ABSTRACT TRUNCATED AT 250 WORDS)”

“The release evoked by GABA , an action mediated by GABAA receptors, was enhanced by chlordiazepoxide and depressed by FG 7142.”

“2 Chlordiazepoxide (1 μm to 28.9 μm) and flurazepam (145–725 nm) increased the responses of the ganglion to GABA and the increases were antagonized by Ro 15–1788, at 3.34 μm.”