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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Chloramphenicol
supplement:
Tryptophan
Research Papers that Mention the Interaction
“When translation was blocked by chloramphenicol , the constitutive synthesis of trp mRNA corresponding to the distal trp genes was abolished, while synthesis of a small initial trp mRNA fragment continued.”
Translation-uncoupled transcription of promoter-proximal DNA sequences in E. coli strains harboring mutationally-generated constitutive promoters within genes of the trp operon“Binding of chloramphenicol shortens the fluorescence lifetimes of all three tryptophans to some extent, in particular those of Trp-86 and Trp-152 (decreases of 51% and 39%, respectively).”
“In contrast the frequency of UV-induced mutations to Trp + (largely at suppressor loci) was drastically reduced by CAP pretreatment, confirming the need for an active replication fork for UV-mutagenesis at these loci.”
“They implicated RNA synthesis on the basis of this result and the finding that the inhibitory effect of 5-methyl tryptophan could be partially reversed (with respect to RNA synthesis and thymineless killing) by chloramphenicol.”
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