Possible Interaction: Chloramphenicol and Phenylalanine

“ Chloramphenicol has been shown to inhibit the intestinal transport of phenylalanine in animals.”

“Summary Parenteral administration of phenylalanine in a dose equivalent to that of chloramphenicol enhanced the antibacterial effect of chloramphenicol in mice infected with Klebsiella pneumoniae.”

“The interaction of phenylalanine and chloramphenicol is discussed in relation to bacterial and mammalian cell protein synthesis.”

“ Chloramphenicol , sodium azide, and dinitrophenol all inhibited the initial uptake rate of leucine and phenylalanine.”

“ Abstract Chloramphenicol at a constant concentration inhibited the polymerization of phenylalanine in a bacterial ribosome-polyuridylic acid system by a constant percentage when graded concentrations of ribosomes, polyuridylic acid, or transfer ribonucleic acid limited the activity of the system. [”

“The oxidation of succinate, dl -malate, and dl -phenylalanine was strongly inhibited by chloramphenicol in sensitive organisms but was inhibited to a much smaller extent in resistant organisms.”

“ACCORDING to Woolley1, chloramphenicol inhibits the utilization of phenylalanine in E. coli, due to its structural resemblance to that amino-acid.”

“ Chloramphenicol , streptomycin, terramycin and aureomycin inhibit the oxidation and to a lesser extent the deamination of phenylalanine , tyrosine and phenylserine by a strain of Pseudomonas aeruginosa.”