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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Chloramphenicol
supplement:
Leucine
Research Papers that Mention the Interaction
“Incorporation of leucine in vitro by mitochondria was increased 27% over control at 24 hr; chloroamphenicol , but not cycloheximide, inhibited the in vitro incorporation.”
Biogenesis of mammalian mitochondria in the renoprival kidney. I. Amino acid incorporation and respiratory activity.“ Chloramphenicol had no effect upon the incorporation of leucine into total protein, and only slightly inhibited the cycloheximide-resistant incorporation of leucine.”
“The rate of leucine uptake into mitochondria was decreased at least fivefold in the presence of chloramphenicol , suggesting that leucine is used mainly for protein synthesis.”
Effect of temperature on protein synthesis and leucine transport by yeast mitochondria.“ Chloramphenicol , sodium azide, and dinitrophenol all inhibited the initial uptake rate of leucine and phenylalanine.”
“In a parallel experiment, leucine uptake into protein was profoundly blocked by chloramphenicol , but only slightly by habekacin.”
“The incorporation of leucine into protein by etioplasts and chloroplasts from pea and wheat was inhibited by chloramphenicol , and to a slight extent by cycloheximide.”
“Poly (U,G) stimulated incorporation of phenylalanine, leucine and glycine into acid-insoluble material, and leucine incorporation in this system was as sensitive to inhibition by chloramphenicol as with ribosomes from E. coli .”
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