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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Chloramphenicol
supplement:
Glutathione
Research Papers that Mention the Interaction
“Depletion in compounds acting as cellular antioxidants, such as glutathione and vitamin E, may conceivably increase the vulnerability of an individual to chloramphenicol toxicity, while supplementation with an antioxidant might protect against it.”
Chloramphenicol toxicity.“Primaquine, chloramphenicol and sulfanilamide caused significant concentration-dependent reductions of glutathione levels in G6PD-deficient red cells when compared to normal red cells.”
“The glutathione S-transferases of human fetal and neonatal liver catalyse the conjugation of glutathione with chloramphenicol at a low but measurable rate.”
“ Glutathione increased the formation of deschloro-chloramphenicol by 13% and decreased the amount of the irreversibly bound product by 18%, respectively.”
Reductive dechlorination of chloramphenicol by rat liver microsomes.
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