Possible Interaction: Chloramphenicol and Glucose

“The presence of glucose and acetamide increased the growth and substrate degradation rates of CAP.”

“Instead, chloramphenicol induced a significant 23% decrease in the regional cerebral metabolic rate for glucose.”

“ CAP produced an increase in the mucosal transference of glucose in jejunum and a decrease in ileum.”

“ Chloramphenicol also inhibited all three processes; the inhibition of protein and RNA synthesis was reversed by glucose , but the inhibition of DNA synthesis was slightly greater in the presence of glucose.”

“The results are consistent with the possibility that chloramphenicol inhibits DNA synthesis in whole cells in the presence of glucose because the antibiotic undergoes metabolism, possibly reduction, in cells, and that a p-nitro group is important for this effect.”

“In the presence of glucose , serine uptake was inhibited by chloramphenicol but not cycloheximide.”

“ Glucose also stimulates the loss of aspartokinases and glutamine synthetase in the presence of chloramphenicol.”

“ Chloramphenicol inhibited the development of aggregating ability in the presence of glucose or sucrose.”

“This so-called priming effect of glucose was observed also in the presence of chloramphenicol , inhibiting the growth of the bacteria.”

“The appearance of glucosyltransferase in the glucose medium was inhibited immediately by chloramphenicol and actinomycin D and, after a lag, by rifampin as well.”

“Respiratory-deficient mutants produced by acriflavine, and wild-type cells grown on glucose in the presence of chloramphenicol had elevated alcohol dehydrogenase activities compared with the wild-type cells grown on glucose.”