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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Chlorambucil
supplement:
Progesterone
Research Papers that Mention the Interaction
“… Cbl … progesterone at 10(-5) M. These results indicate that progesterone is implicated in insulin resistance during pregnancy by inhibiting the PI 3-kinase pathway at … expression and 2) distal to Akt and 3) by suppressing the PI 3-kinase-independent pathway of TC10 activation by affecting Cbl phosphorylation.”
Progesterone inhibits glucose uptake by affecting diverse steps of insulin signaling in 3T3-L1 adipocytes.“ Progesterone also increased the therapeutic index of chlorambucil in the rat by decreasing its systemic toxicity.”
“The steroids prednisolone and progesterone significantly altered the therapeutic indices of the alkylating agents, nitrogen mustard, melphalan, cyclophosphamide, phenyl acetic mustard and chlorambucil.”
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