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Last Updated: 3 years ago

Possible Interaction: Chlorambucil and Polyphenols

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drug:

Chlorambucil

supplement:

Polyphenols

Research Papers that Mention the Interaction

“The plant polyphenols namely tannic acid, butein, quercetin, morin, 2-hydroxychalcone and 2'-hydroxychalcone at 40 microM inhibited the GST-mediated conjugation of CMB with GSH by 38 to 62%.”

Conjugation of chlorambucil with GSH by GST purified from human colon adenocarcinoma cells and its inhibition by plant polyphenols.

Life sciences • 2003 | View Paper

“At micromolar concentrations, five polyphenols , namely quercetin, butein, tannic acid, 2'-hydroxychalcone and morin, inhibited the efflux of CMB significantly; an inhibition of 40% was observed with 10 microM quercetin.”

Glutathione conjugation of chlorambucil: measurement and modulation by plant polyphenols.

The Biochemical journal • 1997 | View Paper

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