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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Chlorambucil
supplement:
Methionine
Research Papers that Mention the Interaction
“Using the PamGene platform, we found that inhibition of MET and RON was associated with decreased phosphorylation of CBL , PI3K, and STAT3.”
Dramatic antitumor effects of the dual MET/RON small-molecule inhibitor LY2801653 in non-small cell lung cancer.“Many receptor tyrosine kinases (RTKs, such as EGFR, MET ) are negatively regulated by ubiquitination and degradation mediated by Cbl proteins , a family of RING finger (RF) ubiquitin ligases (E3s).”
“Moreover, Cbl loss not only uncouples Met from Cbl-mediated negative regulation but also releases other Cbl targets, such as the EGF receptor, from Cbl-mediated signal attenuation.”
“Moreover, exogenous supplementation of Met also restores the impaired QC activity and the root growth defects of cbl.”
Cystathionine beta-lyase is crucial for embryo patterning and the maintenance of root stem cell niche in Arabidopsis.
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