Possible Interaction: Chenodeoxycholate and Phosphatidylserine

“ Chenodeoxycholate and deoxycholate also caused an approximately 1.3-fold enhancement of PKC activity in the presence of 12-O-tetradecanoyl phorbol 13-acetate (TPA) and PS , and the absence of added Ca2+.”

“ Chenodeoxycholate and deoxycholate appear to inhibit PKC by interactions with both Ca2+ and PS , since their inhibitory potencies are reduced at an elevated PS concentration and since both of these bile acids actually enhance PKC activity, approximately 2-fold, when assayed at an elevated Ca2+ concentration (2 mM).”