Possible Interaction: Ceruletide and Secretin

“ Cerulein and secretin acting together increased protein concentration.”

“Secretin alone decreased salivary flow rate and bicarbonate concentration, whereas secretin supplemented with cerulein not only decreased salivary flow rate, bicarbonate concentration, and bicarbonate output but also increased protein concentration.”

“The inhibitory effect of cerulein on salivary flow rate and bicarbonate concentration and output prevailed when an infusion of cerulein was supplemented with secretin.”

“Salivary secretions were collected under basal conditions (intravenous infusion of 0.15 mol l-1 NaCl) and during intravenous infusion of secretin plus caerulein at different doses.”

“Therefore, one may suppose that caerulein plus secretin , used in functional exploration of the exocrine pancreas, could exert an influence on acid phosphatase activity (AcP) and its isoenzymes (tartrate sensitive-TsAcP, tartrate resistant-TRAP acid phosphatases) in whole saliva in humans.”

“Infusion of secretin plus cerulein caused a several-fold increase in the volume of duodenal aspirate and the outputs of HCO3−, protein, and enzymes.”

“After 45 minute of intravenous infusion of secretin (1 CU/kg) and cerulein (75 ng/kg) the decrease of plasma amino acid concentration was significantly lower (p < or = 0.001) than in undernourishment not depending on pancreas dysfunction, nor in patients with chronic pancreatitis with normal nutritional status.”

“After 45 minutes of intravenous infusion of secretin (1 CU/kg) and cerulein (75 ng/kg) we found a significantly lower (p 0.05) decrease of amino acid concentration than in healthy individuals, both in chronic pancreatitis and in undernutrition and post-inflammatory cirrhosis with decompensation of liver function.”

“The peak decrease of amino acids occurred after 30 min during combined stimulation with secretin and ceruletide and was not different between the two groups (CP: 11.2 +/- 1.7%, controls: 13.9 +/- 1.9% below basal values).”

“Potentiation (more-than-additive response) was observed between secretin and cerulein for bicarbonate secretion, but not for enzyme secretion.”

“ Caerulein added to glucagon or secretin could slightly increase the inhibitory effect of these drugs given separately.”

“During administration of both secretin plus cholecystokinin-pancreozymin (CCK-PZ) or secretin plus caerulein , enzyme secretion was promptly reduced by an infusion of calcitonin of more than 50%.”

“The effects of 100 nM secretin with 1 nM caerulein were also studied because secretin may potentiate the effects of caerulein.”