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“It has been reported that melatonin can alleviate cerulein ( Cer ) or Cer + lipopolysaccharide (LPS)‑induced inflammatory responses in AR42J rat pancreatic acinar cells (AR42J cells).”
“Results showed that the administration of melatonin reduced histological damage induced by caerulein treatment as well as the hyperamylasemia and hyperlipidemia.”
“Moreover, we found that cerulein administration wasassociated with stomach edema as well as high levels oflipid peroxidation in the stomach and smallintestine, which were also reduced by melatonin.”