Possible Interaction: Cephaloridine and Glutathione

“ Cephaloridine depletes reduced glutathione , increases oxidized glutathione and induces lipid peroxidation in renal cortical tissue.”

“Low cytotoxic doses of CPH induced an early increase of glutathione phase II-dependent detoxification enzymes.”

“ Total glutathione levels were diminished more rapidly in normoglycemic than diabetic tissue by incubation with 5 mM cephaloridine.”

“ Cld did not cause any significant changes in tissue malondialdehyde (MDA) content in vivo at any of the time points examined, but it did cause a depletion of GSH to approximately 40% of control by 1 hr after dosing that recovered toward control by 6 hr.”

“In vitro, Cld causes GSH depletion, lipid peroxidation, and inhibition of rat kidney slice organic ion uptake.”

“This species-dependent susceptibility to cephaloridine nephrotoxicity appears to be related to the degree in which cephaloridine depletes renal cortical glutathione.”

“In the present study, cephaloridine markedly decreased GSH in rat and rabbit renal cortex while concomitantly increasing oxidized glutathione (GSSG).”

“Recently cephaloridine has been shown to deplete reduced glutathione ( GSH ) concentration selectively in renal cortex.”

“ Cephaloridine produced a dose-related depletion of renal cortical glutathione one hour following a single administration of the drug.”

“These results suggest that glutathione may play a protective role against cephaloridine but not gentamicin nephrotoxicity.”

“Furthermore, cephaloridine produced a dose-related depletion of glutathione in the renal cortex but not in the medulla shortly after the injection.”