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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Cephalexin
supplement:
Progesterone
Research Papers that Mention the Interaction
“The apical-to-basolateral transport of cephalexin was significantly decreased by the progesterone and norethisterone (30 microM each) pretreatments.”
Effects of progesterone and norethisterone on cephalexin transport and peptide transporter PEPT1 expression in human intestinal cell line Caco-2.“ Progesterone … cephalexin uptake in a concentration-dependent manner, and the IC(50) value was calculated to be 2.3 microM. A significant decrease in cephalexin uptake … maximal when the monolayers were treated for 24-72 h. Cephalexin uptake was significantly inhibited by treatments with 17alpha-hydroxyprogesterone, norethisterone, and chlormadinone.”
“The J(max) of cephalexin uptake with progesterone and norethisterone treatments was significantly decreased compared with the control, whereas K(m) and K(d) values were not affected.”
“The saturable component of cephalexin uptake was markedly inhibited by progesterone and norethisterone treatments.”
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