Possible Interaction: Central Nervous System Stimulants and Yohimbine

“ Yohimbine inhibits …,3may stimulate serotonin receptors,4and, above all, may induce a preferential destruction of newly synthesized dopamine and a depletion of stored noradrenaline.5Thus, when using such a complex pharmacologic tool as yohimbine, it is not possible to draw any direct clinical inference by ascribing it to only”

“Dex, imidazoline, yohimbine , and rauwolscine reduced the increases in contraction tension induced by the receptor stimulant adrenaline.”

“The stimulant amphetamine also reduced submissive behavior while yohimbine (also a stimulant), and the antianxiety agent diazepam had no such effect.”

“Representative isobolograms plotted for each drug interaction illustrate that a beta-adrenoceptor agonist (isoproterenol), selective beta 2-adrenoceptor agonists (salbutamol, terbutaline), alpha 1- and alpha 2-adrenoceptor antagonists yohimbine , phentolamine, prazosin), as well as the stimulant caffeine, strongly potentiate the lethal effect of PB.”

“ Yohimbine hydrochloride is an indole alkaloid which blocks alpha 2-adrenergic and dopamine receptors and stimulates serotonergic receptors.”