Possible Interaction: Central Nervous System Stimulants and Tretinoin

“We also provide evidence that RA induces the generation of Ngn3+ endocrine progenitor cells and stimulates their further differentiation into β-cells by activating a program of cell differentiation that recapitulates the normal temporal program of β-cell differentiation.”

“Furthermore, BMP and retinoic acid signaling cooperate to stimulate cell proliferation, repress adipogenesis, and promote osteoblast differentiation.”

“It is demonstrated that retinoids inhibit the growth and enhance the differentiation of melanoma cells in vitro, and stimulate the constitutive melanogenesis in melanoma cells in vitro.”

“ Retinoids can inhibit the proliferation and stimulate differentiation of NB cells.”

“We conclude that retinoic acid can inhibit proliferation and stimulate differentiation in Caco-2 cells depending on concentration and cell stage, and that these effects are accompanied by changes in distribution, as well as by the loss of RARβ.”

“The mechanism by which retinoids decrease the proliferation of different tumor cells and, sometimes, stimulates cell differentiation (3,24,25) remains unclear.”

“In this paper we show that treatment of EBV-negative and EBV-positive BL cell lines with all-trans retinoic acid also stimulates an increase in c-fgr mRNA levels, varying between 2- and 13-fold depending on the cell line.”

“These findings suggest, that RA inhibits the proliferation of neoplastic keratinocytes and stimulates the proliferation of normal epidermal cells.”

“Supplementation studies revealed that RA stimulates lung branching in a dose-dependent manner.”

“Since retinoids block the light-regulated ion channels (Dean et al. 2002) and stimulate the activity of opsin, it is no wonder that isolated mouse rods are overwhelmed by relatively small bleaches.”