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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Sphingosine 1-Phosphate
Research Papers that Mention the Interaction
“These findings help explain why S1P and GF synergize to stimulate robust sprouting in 3D collagen matrices.”
Calpain-mediated vimentin cleavage occurs upstream of MT1-MMP membrane translocation to facilitate endothelial sprout initiation“Consistently, S1P also dramatically stimulates Ang2 exocytosis from the ECs of ex vivo–incubated blood vessels.”
“These results show that in non-transformed cells, S1P induces a rearrangement of the actin cytoskeleton and stimulates proteolytic activity on cell surfaces.”
“Since S1P was previously shown to inhibit myoblast proliferation and stimulate myogenesis, the here identified novel biological activity is in favour of a complex physiological role of the sphingolipid in the process of muscle repair.”
Sphingosine 1-phosphate inhibits cell migration in C2C12 myoblasts.“We also found that sphingosine-1-phosphate potently stimulates the phosphorylation of both ERK and Akt, which are involved in the cell survival-signalling cascade.”
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