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Last Updated: 2 months ago

Possible Interaction: Central Nervous System Stimulants and Secretin

Research Papers that Mention the Interaction

In the small bowel, CCK, gastrin, motilin, VIP, and glucagon stimulate contractions, while secretin inhibits contractions.
World Journal of Surgery  •  2005  |  View Paper
In addition, secretin induces sustained mitogen-activated protein kinase (MAPK) activation and also stimulates the cAMP secretion.
Experimental & Molecular Medicine  •  2006  |  View Paper
Acid secretion elicited by these stimulants was significantly inhibited (P<0.05 to 0.001) by intravenous infusion of secretin , 2 (units/kg)/hr.
The American Journal of Digestive Diseases  •  2005  |  View Paper
We found that secretin can stimulate HCO3- secretion in guinea pig pancreatic ducts about fivefold and that this effect could be totally blocked by SP.
American journal of physiology. Cell physiology  •  2003  |  View Paper
This phasic response suggests that secretin could act on acid secretion by releasing mediators which stimulate (as gastrin) and/or inhibit (as somatostatin) acid output.
Digestion  •  1984  |  View Paper
However, peptic secretion increased significantly when either acid stimulant was infused simultaneously with a dose od Boots' secretin , in itself below the threshold for peptic stimulation.
The Journal of physiology  •  1979  |  View Paper
In the presence of secretin the E.D.50 of each acid stimulant was lowered.
The Journal of physiology  •  1976  |  View Paper
The proposed explanation for the potentiation … the peptic response when an acid stimulant is infused along … a dose of secretin , in itself below the threshold of peptic stimulation, is that each acid stimulant increases gastric … blood flow, approximately doubling the effective concentration of secretin delivered to the peptic cell.
The Journal of physiology  •  1975  |  View Paper