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The American Journal of Digestive Diseases • 2005 | View Paper
“We found that secretin can stimulate HCO3- secretion in guinea pig pancreatic ducts about fivefold and that this effect could be totally blocked by SP.”
American journal of physiology. Cell physiology • 2003 | View Paper
“This phasic response suggests that secretin could act on acid secretion by releasing mediators which stimulate (as gastrin) and/or inhibit (as somatostatin) acid output.”
“However, peptic secretion increased significantly when either acid stimulant was infused simultaneously with a dose od Boots' secretin , in itself below the threshold for peptic stimulation.”
“The proposed explanation for the potentiation … the peptic response when an acid stimulant is infused along … a dose of secretin , in itself below the threshold of peptic stimulation, is that each acid stimulant increases gastric … blood flow, approximately doubling the effective concentration of secretin delivered to the peptic cell.”