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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
S-Adenosylmethionine
Research Papers that Mention the Interaction
“Clinical trials have shown reduced pain and stiffness while in vitro and animal studies have shown SAMe can stimulate the production of cartilage which is critical in reversing the disease process.”
Exploring the Mechanisms behind S-Adenosylmethionine (SAMe) in the Treatment of Osteoarthritis“We also show that HGF- and AICAR-induced AMPK activation stimulate the transport from nucleus to cytoplasm of HuR, an RNA-binding protein that increases the half-life of target mRNA such as cyclin A2, and that SAM blocks this process.”
S-adenosylmethionine regulates cytoplasmic HuR via AMP-activated kinase.“This means that SAM inhibits WEN1 but stimulates WEN2.”
Processing character of the action of wheat endonucleases WEN1 and WEN2. Kinetic parameters“ AdoMet markedly stimulates the enzyme in a reversible and cooperative manner, consistent with its proposed role in regulation of methionine biosynthesis.”
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