Possible Interaction: Central Nervous System Stimulants and Resveratrol

“ Resveratrol and melatonin have been shown to increase SIRT1 activity and stimulate deacetylation.”

“The higher levels of resveratrol tested (0.006% in food or 100 mg in slow-release pellets) tended to stimulate tumor growth (P = 0.08-0.09).”

“It has been shown that formulations with resveratrol can stimulate the proliferation of fibroblasts and contributing to the increase in the concentration of collagen III.”

“In moderate RC-deficient patients' cells, RSV treatment increases the amount of mutated proteins and stimulates residual enzyme activities.”

“BACKGROUND Animal and in vivo studies indicate that re veratrol in creases SIRT1 expression that sti mulates PG C1α activity.”

“Here we show that resveratrol inhibits human Sirt3 and stimulates Sirt5, in addition to Sirt1, against fluorophore-labeled peptide substrates but also against peptides and proteins lacking the non-physiological fluorophore modification.”

“These results collectively demonstrate that CTN stimulates ROS generation and JNK activation for mitochondria-dependent apoptotic signaling in Hep G2 cells, and these apoptotic biochemical events are blocked by pretreatment with resveratrol , which exerts antioxidant effects.”

“ RSV inhibits survivin expression and stimulates mitochondrial depolarization, caspase 7 activation and cell death.”

“Results We first found that LPS could stimulate SphK1/S1P axis activation, whereas this occurrence was significantly blocked by RSV pretreatment.”