Possible Interaction: Central Nervous System Stimulants and Niacin

“Our findings indicate that an interaction between muscarinic and nicotinic agonists synergistically stimulates anion secretion in mouse jejunal epithelial cells and identify a role for epithelial nicotinic receptors in anion secretion.”

“Moreover, nicotinic acid prevents the up-regulation of ICAM-1 triggered by the pro-inflammatory cytokine TNF-α and stimulates the formation of endothelial tubes through GPER in HUVECs.”

“Preclinical and clinical studies suggest a facilitatory role of nicotinic agonists for stimulant addiction.”

“ Niacin has also been shown to interfere with the cyclic AMP (cAMP)/protein kinase A (PKA) pathway and massively stimulate prostaglandin D2 (PGD2) formation.”

“Nicotinamide was found to be nontoxic at the highest concentrations employed (10(-2)M) and suppressive over a relatively broad range (10(-…)M. The suppression appeared to be related to the magnitude of antigen- or mitogen-induced transformation and was apparent even when nicotinamide was added … hr after stimulant ….”

“ NA potentiates the effect of 131I by increasing eNOS, which would in turn stimulate NO production, increasing thyroid blood flow and tissue damage via organic peroxides.”

“We have found that agents that stimulate protein kinases or that inhibit phosphoprotein phosphatases will decrease the rate of desensitization during repeated stimulation by either a nicotinic agonist or by a depolarizing concentration of KCI.'”

“Several agents which mimic cyclic AMP or stimulate cyclic AMP production in the ganglion enhance nicotinic transmission for several hours.”