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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Melatonin
Research Papers that Mention the Interaction
“ Melatonin improves sleep habits, reduces anxiety and stimulates immunity.”
Can melatonin reduce the severity of COVID-19 pandemic?“Moreover, melatonin potently stimulates DNA damage responses that increase the tolerance of normal tissues to toxic effect of IR and may reduce the risk of genomic instability in patients who undergo radiotherapy.”
“Resveratrol and melatonin have been shown to increase SIRT1 activity and stimulate deacetylation.”
“2) In pancreatic carcinoma cell line (PANC-1) melatonin used at high doses affects the Bax/Bcl protein balance, and stimulates the expressions of caspase-9 and caspase-3, thus activating the mitochondrial pathway of apoptosis.”
“ Melatonin not … stimulates the production of natural killer cells, monocytes and leukocytes, but also alters the balance of T helper (Th)-1 and Th-2 cells … towards Th-1 responses and increases the production of relevant cytokines such as interleukin (IL)-2, IL-6, IL-12 and interferon-γ.”
“ Melatonin modifies adenohypophysial hormone synthesis and secretion either directly by influencing the secretory activity of the cells in the anterior pituitary or indirectly by influencing the hypothalamic neurons producing the respective neurohormones which stimulate or inhibit the release of adequate adenohypophysial hormones.”
“ Melatonin has been shown to either stimulate gene expression for the antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase) or to increase their activity.”
“Investigation of the PI signal transduction cascade activated by either the …) melatonin receptor expressed in Chinese hamster ovary (CHO) cells showed that melatonin (1pM … stimulate the formation of PIs to approximately 40-60% over basal [EC(50): …-300nM) and MT(2)=1.1nM (0.32-3.5nM), N=5].”
“While melatonin inhibits tumor linoleic acid uptake, metabolism and growth, pinealectomy or constant light exposure stimulates these processes.”
“At the systemic level, Mt decreases hormonal production, stimulates immune activity, and prevents the development of metabolic syndrome.”
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