Possible Interaction: Central Nervous System Stimulants and Marijuana

“Although the detailed mechanism of action has not been elucidated, there is evidence that marihuana produces both sympathetci nervous system stimulation and parasympathetic nervous system blockade.”

“Fatal opioid overdoses involving stimulants had higher frequencies of illicit drugs on toxicology specifically marijuana , fentanyl, and heroin compared to fatal opioid overdoses without stimulants.”

“Past-year tobacco and alcohol use, and past-year misuse of prescription sedatives or tranquilizers, stimulants , and opioids were associated with increased adjusted relative risk ratios across all levels of cannabis use compared to youth reporting no lifetime cannabis use.”

“Sub-analyses revealed that cannabis use was negatively associated with initiation of injection stimulants but not initiation of injection opioids.”

“Arria et al. (2013) found an association between cannabis use disorder and nonmedical use of prescription stimulants for studying, reduced class attendance, and declining academic performance.”

“We tested the hypothesis that stimulants would decrease marijuana use in a randomized controlled trial of extended release mixed amphetamine salts (MAS-XR) for treatment of co-occurring ADHD and cocaine use disorders.”

“Alcohol, smoking, stimulant and other recreational drug use were associated with increasing marijuana use across all four trajectory groups.”

“With the successful treatment of adult ADHD, stimulants generally also lower the urge to use alcohol or marijuana.”

“Taken together, these findings suggest that stimulant use amongst cannabis users rather than cannabis use alonemay enhance the impact of childhood trauma on the likelihood of developing psychotic disorder.”

“Multivariate analyses revealed that selling drugs and using marijuana and other illegal drugs were associated with increased odds of both methamphetamine and nonmedical prescription stimulant use.”