Possible Interaction: Central Nervous System Stimulants and Leucine

“ Leucine is a particularly potent regulator of protein turnover, to the extent where leucine stimulation alone is sufficient to stimulate mTORC1 signal transduction.”

“Studies both in vivo and in vitro have shown that leucine at a very high dose can stimulate muscle protein synthesis, an effect that is enhanced in vivo by insulin secreted in response to the leucine dose.”

“The addition of leucine to regular meals may improve the ability of feeding to stimulate protein synthesis in old human muscle.”

“These results indicate that chronic administration of leucine may stimulate oxidative stress and alters the enzymes of phosphoryltransfer network in the cerebral cortex and hippocampus of the rats.”

“ 4-Methylvaleric acid very strongly inhibited the transamination of all the branched-chain 2-oxoacids and blocked their capacity to decrease islet GABA and to stimulate insulin secretion.”

“The signal induced by leucine or arginine may stimulate cell growth.”

“The addition of 10(-7) M TRH showed that leucine can be limiting in the response to this stimulant and allowed a response to as little as 10 mg/liter leucine to be discerned.”

“The presence of 2 mM leucine in the mucosal solution markedly stimulates the rate of net lysine transport across short-circuited segments of rabbit ileum.”

“Cells do not multiply in suspension culture but do multiply in monolayer culture and thus there is a correlation between uptake of leucine and conditions which stimulate cell multiplication, but no correlation of the uptake of deoxyglucose, uridine and adenosine with these conditions.”