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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glucosamine
Research Papers that Mention the Interaction
“Exposure to glucosamine also resulted in a reduction in the ability of IGF-I or insulin to stimulate phosphorylation of insulin IGF-I/HRs.”
Glucosamine induces resistance to insulin-like growth factor I (IGF-I) and insulin in Hep G2 cell cultures: biological significance of IGF-I/insulin hybrid receptors.“Again, both HG and GlcN significantly reduced insulin's ability to stimulate PKB activity.”
Glucose-induced insulin resistance of phosphatidylinositol 3'-OH kinase and AKT/PKB is mediated by the hexosamine biosynthesis pathway.“The [3H]thymidine incorporation was markedly suppressed by macrophage stimulants such as muramyl dipeptide (MDP) or bacterial lipopolysaccharide (LPS), while glucosamine incorporation was simultaneously increased by these stimulants.”
“Thus, it is suggested that the systemic administration of glucosamine in dogs may stimulate IRG secretion by some indirect effect.”
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