Possible Interaction: Central Nervous System Stimulants and Epinephrine

“Since the concept of the autonomic nervous system regulating the peripheral endocrine system was not considered likely at that time, we performed a number of control studies to stimulate the p-cell with glucose and other insulin secretagogues; all were inhibited by epinephrine.”

“Half-maximal effective dose for insulin's effect to stimulate WBGU, delta AVG, BF, and LGU was increased two- to threefold during Epi vs. saline infusions (P less than 0.01 for all values).(ABSTRACT TRUNCATED AT 250 WORDS)”

“We hypothesized that the use of a stimulant of a-admenengic pnesynaptic receptors, which reduces the melease of nomepinephrine (3), might be effective in the treatment of manic states.”

“In the presence of insulin adrenaline markedly stimulates oxygen uptake; glucose is required for this effect.”

“It has long been recognized that the administration of epinephrine stimulates the waking state and increases spontaneous motor activity.”

“However, immediately after the pretreatment with epinephrine , the Ca(2+) transients evoked by chemical stimulants (capsaicin, KCl, and ATP) were markedly potentiated; for example, capsaicin (50 nM, 15 s)-evoked Ca(2+) transient was increased by 106% after epinephrine (P < 0.05; n = 11).”

“Short-term (30 min) exposure to epinephrine (100 nM) stimulates the rate of beta 2AR gene transcription, resulting in a 3- to 4-fold increase in steady-state beta 2AR mRNA levels.”

“It is concluded that adrenaline is able both to inhibit the synthesis of lipoprotein lipase and to stimulate its degradation.”

“ Adrenaline also produced a stimulant effect on the sport aneously contracting preparations of the central portions of the ureters.”

“ Epinephrine and estradiol significantly stimulate acetylation of H1 and H3 respectively in the young.”