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Journal of cardiovascular medicine • 2017 | View Paper
“Most drugs that enhance brain dopamine levels (e.g. DAT blockers like cocaine and methylphenidate) produce behavioral effects like those of stimulants causing them to be abused.”
European journal of pharmacology • 2013 | View Paper
“However, clinical trial eligibility criteria excludes most high-risk patients from participating, and introducing stimulant substitution to the wider treatment community would likely expose more vulnerable patients to the medical risks associated with stimulant treatment while using cocaine.”
“Converging evidence indicates that repeated exposure to motor stimulants such as cocaine and amphetamine produces marked alterations in network responsiveness of striatal neurons to subsequent challenge with the same stimulant drug.”
Neurobiology of Learning and Memory • 2005 | View Paper
“In recent years, use of cocaine and amphetamines and deaths associated with stimulants have been on the rise, and there are still no FDA-approved medications for stimulant use disorders.”
Handbook of experimental pharmacology • 2020 | View Paper
“Significant contributing cardiac conditions were associated with higher adjusted odds of stimulant compared to opioid (aOR = 1.46, 95%CI = 1.19-1.79, p < 0.01) and cocaine compared to MAMP death (aOR = 1.66, 95%CI = 1.13-2.45, p = .01).”
“There was a significant decrease in striatal dopamine release in stimulant users compared with healthy controls: the effect size was −0.84 (95% CI, −1.08 to −0.60; P < .001) for stimulants combined and −0.87 (95% CI, −1.15 to −0.60; P < .001) for cocaine.”
“Since preclinical … to stimulant drugs during the period corresponding with adolescence, but not … with childhood, increased sensitivity to the rewarding effects of cocaine (8), prospective studies of larger samples of adolescents treated with stimulant medications are … to more carefully evaluate the consequences of stimulant exposure during this developmental period.”