Possible Interaction: Central Nervous System Stimulants and Cobalt

“~ …cobalt … stimulates EPO gene expression, possible by interfering with the mechanism of oxygen sensing.6 Run-on experiments in rats and hepatoma cells have shown that … expression primarily by stimulating transcription of the EPO gene.’v8 This transcriptional activation is mediated by a mechanism that requires active protein synthesis.”

“This stimulant action is mediated through atropine-sensitive receptors and is blocked by certain calcium antagonists such as local anesthetics, cobalt , magnesium, and phenoxybenzamine.”