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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Berberine
Research Papers that Mention the Interaction
“ BRB inhibits mitochondrial complex I partially and thereby cause increased AMP/ATP ratio, which stimulates AMPK activity (Thr 172 phosphorylation).”
Adenosine monophosphate-activated protein kinase modulation by berberine attenuates mitochondrial deficits and redox imbalance in experimental diabetic neuropathy“These results suggest that BBR acutely stimulates both AMPKα1 and AMPKα2 and insulin-independent glucose transport in skeletal muscle with a reduction of the intracellular energy status.”
“Together, we concluded that berberine increases glucose transport activity of 3T3-L1 adipocytes by enhancing GLUT1 expression and also stimulates the GLUT1-mediated glucose uptake by activating GLUT1, a result of AMPK stimulation.”
“These results suggest that berberine circumvents insulin signaling pathways and stimulates glucose uptake through the AMP-AMPK-p38 MAPK pathway, which may account for the antihyperglycemic effects of this drug.”
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