Possible Interaction: Central Nervous System Stimulants and Arachidonic Acid

“Studies suggest that AA can stimulate superoxide production, induce degranulation, suppress cell chemotaxis and down-regulate expression of occluden, a transmembrane protein integral in the formation of tight junctions (6).”

“For example, AA inhibits gap junctional permeability between adherent cells2, stimulates Superoxide production, degranulation and upregulates CDllb/CD18 expression in human neutrophils3, stimulates insulin secretion4, modulates the permeability of ion channels5–7 and stimulates gene transcription8.”

“In addition, ATP is shown to inhibit, and phosphatidylcholine is shown to stimulate , 15-lipoxygenase, suggesting a regulatory role for these compounds in the lipoxygenation of arachidonic acid.”

“Higher concentrations of AA (0.5-50 microM) stimulate the formation of a further amount of PA (200-250%), and phosphorylation of 40,000 molecular weight protein, platelet aggregation, and serotonin release.”

“Studying Swiss 3T3 fibroblasts, we report that arachidonic acid strongly stimulates mRNA levels of the growth-associated immediate early genes c-fos and Egr-1.”

“ AA was shown to act in a time- and dose-dependent manner to stimulate testosterone production.”

“The rate of arachidonic acid liberation varied from one stimulant to the other.”

“It has been found that 8 out of 10 stimulants also induce arachidonic acid (20:4) liberation and thromboxane synthesis.”

“A23187 did … MPs with arachidonic acid and with the arachidonic acid … cAMP levels induced by OB stimulants were enhanced, not blocked, by mepacrine, 5,8,11,14-eicosatetraynoic acid (ETYA), indomethacin or aspirin, … and linoleic acids was blocked by ETYA and indomethacin, indicating that it was mediated by PGs.”

“In recent in vitro studies, we have shown that addition of arachidonic acid (K 1/2 congruent to 10(-6) M) also stimulates secretion, cAMP accumulation, and PGE2 production in rabbit ileal mucosa.”