Possible Interaction: Central Nervous System Stimulants and Adrenocorticotropic Hormone

“We have shown that NO exerts opposite … median eminence‐pituitary axis, where it inhibits ACTH responses to blood‐borne signals [such as the systemic injection of proinflammatory … (VP)], and structures protected by the blood‐brain barrier, where it stimulates the synthesis of the hypothalamic …‐releasing factor (CRF) and VP.”

“TGF-beta 2, TGF-beta 1,2, basic fibroblast growth factor, and angiotensin II also appeared able to stimulate alpha 2-M secretion in BAC cells, whereas adrenocorticotropin was strongly inhibitory.”

“RECENT studies indicate that ACTH can stimulate the salt-regulating function of the adrenal cortex in humans, thereby decreasing the excretion of sodium and increasing that of potassium in the urine (1, 2, 3), and decreasing the sodium concentration of sweat (3, 4).”

“In ZF cells, VIP stimulates cortisol secretion and enhances the steroidogenic action of ACTH.”

“In vivo ACTH stimulates cytosolic PTP activity (2-fold).”

“There is some controversy as to the exact nature of the drive for this pre-partum cortisol surge and it is thought that factors other than ACTH may act in concert to stimulate the development of the fetal adrenal gland.”

“Since ACTH stimulates SS-activity and increases its concentration, the participation of SS and steroid sulfates in corticosteroidogenes could be important.”

“In confirmation of previous studies by others, it is herein shown that high concentrations of ACTH (460 milliunits) and epinephrine (10 -5 m) stimulate the activity of the whole homogenate 2.9-fold and 4.1-fold, respectively, whereas 20 mm fluoride has no effect on its activity.”

“Anaerobiosis stimulates glycolysis, while inhibiting steroid production, and anaerobic glycolysis is significantly depressed by ACTH.”

“It was concluded that ACTH not only stimulates corticosterone formation from both progesterone and pregnenolone, but may also stimulate metabolism of this compound, thus increasing net ‘turnover’.”