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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Ceftriaxone
supplement:
Apigenin
Research Papers that Mention the Interaction
“In checkerboard method apigenin markedly reduced the MIC of the antibiotics ampicillin 800 µg/ml shifted to 107 µg/ml (AM+AP) and ceftriaxone 58 µg/ml shifted to 2.6 µg/ml (CEF+AP) against MRSA.”
“The modulation of methicillin-resistance by apigenin significantly enhanced the activities of ampicillin and ceftriaxone.”
“The result of time-kill assays of the two drug combinations AM +AP and CEF+AP against MRSA showed significant inhibitory … by approximately 99% after 8 h The results for outer membrane (OM) and inner membrane (IM) permeabilization showed that ampicillin and ceftriaxone … apigenin damaged MRSA cytoplasmic … intracellular constituents.”
Synergistic antibacterial effect of apigenin with β-lactam antibiotics and modulation of bacterial resistance by a possible membrane effect against methicillin resistant Staphylococcus aureus.
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