Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Cefdinir and Iron, Dietary

supplement:

Iron, Dietary

Research Papers that Mention the Interaction

The area under the concentration curve [AUC(0–12)] of cefdinir with concurrent iron was significantly smaller than that with cefdinir alone (mean ± SD, 0.78 ± 0.38 versus 10.3 ± 1.35 µg · hr/ml).
These findings suggest that the mechanism of interaction between cefdinir and iron ion preparation is the formation of a chelation complex and that this complex probably restricts gastrointestinal absorption.
Clinical pharmacology and therapeutics  •  1993  |  View Paper
Cefdinir , a third-generation oral cephalosporin frequently used in pediatric populations, may cause red stools when administered with iron or products that contain iron, such as infant formula.
The Journal of the American Board of Family Medicine  •  2008  |  View Paper
With the recent approval of generic formulations of cefdinir , clinicians should be aware of this drug‐drug interaction with iron‐containing products to prevent unnecessary alarm by parents and caregivers, as well as costly medical evaluations for gastrointestinal bleeding.
Pharmacotherapy  •  2008  |  View Paper
There are reports of forming red stool in patients receiving cefdinir along with iron or iron containing preparations.
Journal of family medicine and primary care  •  2020  |  View Paper