Possible Interaction: Catechin and Vitamin C

“ Vitamin C acted as a visco-modulator during C and B β-rays sterilization, modifying graft injectability.”

“In the presence of catechin , a well-known polyphenol found in red wine, ascorbic acid at pH 3.0 works in a synergistic manner preventing lipid peroxidation and beta-carotene cooxidation.”

“Intestinal transport of gallated catechins significantly increased from catechins formulated with vitamin C and xylitol in a dose-dependent manner compared to the catechin-only formulation.”

“In the presence of AA, CTCH depletion was delayed, an effect that was dependent upon the initial concentration of AA.”

“When Vit C and Vit K3 were combined at a C :K3 ratio of 100:1 and administered to the carcinoma cells, the 50% cytotoxic concentrations (CD50) of the vitamins decreased 10- to 60-fold.”

“Regarding antioxidants, … of Vitamin C (P = 0.046) … Group B and C compared to Group A. Moreover, there was significant difference exhibited in concentration level of MDA (P = 0.001) and ….015) between Group B and C, whereas difference of Vitamin C (P = 0.147) was not statistically significant.”

“Adding ascorbic acid during the photolytic treatment of catechin hydrate decreased the dimer formation, suggesting that ascorbic acid can suppress the photosensitive oxidation of catechin.”

“The antioxidant capacity of (+)-catechin was higher than the other isolated compounds as well as the known antioxidant, ascorbic acid.”

“Accumulation of EGC, EGCG and ECG by Caco-2 cells was significantly (P<0.05) higher from GT+S+AA compared to other formulations while retention of catechins was enhanced in presence of ascorbic acid.”

“These data suggest that formulation with sucrose and ascorbic acid may improve catechin bioavailability by enhancing bioaccessibility and intestinal uptake from tea.”

“It was found that the free radical-scavenging activities of catechins are 3.2-13 times larger than that of vitamin C at pH 7.0.”