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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“This study demonstrated that the C and E subunits when assembled as simple or complex heteromeric 5-HT3 receptors may alter efficacies of 5-HT and clinically used antagonists such as ondansetron and palonosetron, and this in turn may have implications for patient responses to therapies.”
The C and E subunits of the serotonin 5-HT3 receptor subtly modulate electrical properties of the receptor.“The mean change and fold increase in IELT and the mean change in serum 5-HT concentrations in group A were significantly higher than those in groups B and C (all P<0.001).”
“The concentration-response curve of serotonin was also shifted to the right by (−)-cyanopindolol (apparent pA2 value: 8.30) and (+)-cyanopindolol (6.83) but not by ICI 118,551 (<5.5).”
Cyanopindolol is a highly potent and selective antagonist at the presynaptic serotonin autoreceptor in the rat brain cortex“When … C, … serotonin (3 minutes post-serotonin: T = 49.0 ± 13.3 mg/mg, C = 27.33 ± 1.8 μmol/kg, compared with control T = −4.…: T = −17.3 ± 2.1, C = 19.3 ± 1.1, compared with control T = −19.6 ± 4.1, C = 18.1 ± 1.4).”
“Five weeks of exposure to 34 and 10--34 degrees C caused declines in 5-HT turnovers.”
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