Possible Interaction: Catechin and Morphine

“RESULTS Twenty-four hour mo phine co nsumption was significantly reduced in Groups B [mean (SD) 24 (14) mg] and C [ 2 5 (19) mg] compared with Group A [47 (28) mg].”

“The purpose of the present study was to investigate whether local application of morphine suppressed the glutamate-evoked activities of C and Adelta primary afferent fibers in dorsal hairy skin of rat in vivo.”

“Thus, &mgr;-opioids such as morphine may act presynaptically to inhibit C , but not A&dgr;, neurotransmission, and postsynaptically on dorsal horn cells that receive input from A&dgr; and/or C fiber nociceptors.”

“ Abstract Morphine (2 × 10−3 M) inhibits the steady-state changes in rat brain slice NAD(P)H and cytochromes a-a3 but not b and c , induced by 30 mM K+ concentrations.”

“ Morphine inhibited the poly I: C induced increase in all tissues and circulating serum.”

“ Morphine concentrations were found to be 95% or greater over 60 days when stored at both 4 deg … 23 deg C. In addition, morphine concentrations were greater than 97% when stored at -20 deg C , and they were 98% or greater when … at 37 deg C after 2 days.”