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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
Research Papers that Mention the Interaction
“4) … of Levodopa required … groups C and E was significantly reduced after treatment (P < 0.05), while in groups D and F, it was unchanged (P > 0.05); …, the further analysis displayed that significant reduction only presented in group C (P < 0.05), not in the other three groups.”
[A multi-centered randomized double-blinded controlled clinical study on efficacy of gulling pa'an capsule in treating Parkinson's disease].“While both tea catechins and quercetin strongly inhibit human liver catechol-O-methyltransferase (COMT)-mediated O-methylation of L-DOPA in vitro, only (+)-catechin exerts a significant inhibition of L-DOPA methylation in both peripheral compartment and striatum in rats.”
Beneficial effects of natural phenolics on levodopa methylation and oxidative neurodegeneration“ L-DOPA at 100 nM increased S and C , which contrasted with no effect in the control slices.”
“ Catechin can enhance L-dopa bioavailability, and both catechin and green tea essence decreased 3-OMD formation.”
“In conclusion, catechin and green tea essence can significantly affect the metabolism of L-dopa by the COMT metabolic pathway.”
“Results indicated that catechin at doses of 10, 20, and 50 mg/kg increased the area under the plasma concentration-time curve from time zero to the time of the last quantifiable concentration (AUC0-t ) of L-dopa by about 69%, 78%, and 42%, respectively.”
Effect of catechin and commercial preparation of green tea essence on the pharmacokinetics of L-dopa in rabbits.
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