Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Journal of pediatric hematology/oncology • 1995 | View Paper
“Some catechins inhibited mammalian pols (α and β) and human topos ( I and II), with (-)-epigallocatechin gallate (EGCg) the strongest inhibitor of both enzyme types, showing IC(50) values of 3.8-21.5 and 2.0-20.0 μM, respectively.”
“Since brother-sister size differences for I2 and P1 showed higher correlations with C than did correlations involving I1 and P2, a field of size differences, centering on the canine, was demonstrated.”
“In an RCT of first-line treatment of MMT, the combination of I and C compared to I alone, resulted in a higher RR (57% versus 39%) and a small improvement in progression-free survival (6.0 vs 4.0 months, p=0.02).”
Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 2004 | View Paper
“We find that the substitution of I for G in a template is strongly inhibitory and prevents any incorporation of C into internal positions in the oligomeric products of the reaction.”
“The equilibration of C and I according to reaction 2 is much slower than the equilibration between C and S in reaction 1 (time-dependent inhibition).”