Possible Interaction: Catechin and Interleukin-10

“The pattern … change in IL-10 , IL-1ra, and IL-8, but … IL-6, differed significantly between the C and the P group, with higher postrace values measured for IL-10 (109% higher) and …-1ra (212%) in the P group and for IL-8 (42%) in the C group.”

“CD40 … C elicited increased production of inflammatory cytokines … and tumor necrosis factor-alpha, of IL-10 and the CCL5 chemokine, but profiles differed as to higher IL-10, IL-12 and CCL22 (a … for T cell recruitment) levels for the former, and of CCL4 and CCL5 for the latter.”

“Results showed that without stimulants, IL‐10 production in mononuclear cells of hepatitis B and C patients was significantly lower than that of healthy subjects (P < .01).”

“ catechin inhibited the gene expression of pro-inflammatory cytokines including IL-1α, IL-1β, IL-6, IL-12p35, and inflammatory enzymes including iNOS and COX-2, but enhanced the gene expression of anti-inflammatory cytokines including IL-4 and IL-10.”

“The combination of Pam3CSK4 and poly I C synergistically upregulated IFN-β, IFN-γ, IL-12, IL-4, and IL-13 transcripts and cross-inhibited IL-1β, IL-10 , and iNOS transcripts in the chicken peripheral blood mononuclear cells (PBMCs) as analyzed by quantitative real-time PCR.”

“FLN and pI C in solution or MP formulation could synergize to activate macrophages and induce higher pro-inflammatory cytokines interleukin (IL)-6, IL-12, interferon-γ and anti-inflammatory cytokines IL-10 compared to single TLR ligand (P<0.05).”

“… IL-10 in groups A [(37.5 +/- 4.6) …], B [(35.0 +/- 5.4) pg/ml], C [(25.0 +/- 5.4) pg/ml] and D [(32.5 +/- 4.6) pg/ml] was lower … of group G [(45.0 +/- 5.4) pg/ml] (P < 0.05 or P < 0.01).”

“The peak level of serum IL-10 (pg/mL) in Group A (249.57±43.51) was significantly higher than in Groups B and C (132.06±17.53, 104.25±13.42, p<0.01).”

“On the other hand, the increase in anti-inflammatory cytokines IL-10 ) was more suppressed in the C and D groups than in the other groups.”