Possible Interaction: Catechin and Hydrogen Peroxide

“ Catechins pretreatment significantly reduced PCOOH-elevated H2O2 amounts, endothelial cell apoptosis and partly recovered eNOS expression.”

“ Hydrogen peroxide has been found to have a distorting … the serological markers of hepatitis B and C , transglutaminase antibodies: an increase in the percent of false higher (anti-HBsAg, HBeAg, anti-HCV) and … the results of PCR-based diagnosis (PCR inhibition that was more pronounced especially in low viremia).”

“In the 7-mo interventional study, the 14 patients who received daily supplementation of catechins for 3 mo had less predialysis plasma hydrogen peroxide activity, lower hypochlorous acid activity, and lower phosphatidylcholine hydroperoxide, C-reactive protein, and proinflammatory cytokine concentrations than did the 30 hemodialysis patients who received placebo.”

“Taken together, our results demonstrate that (+)-catechin inhibits UVB- and oxidative stress-induced H2O2 production and JNK activation and enhances human keratinocyte survival.”

“ (+)-Catechin (10 nM) inhibited not only complex I activity, but also the H2O2 production rate (35%) sustained by malate-glutamate, in accordance with the decrease observed in mitochondrial membrane potential.”

“Altogether, the results indicate that (+)-catechin , at nM concentrations, inhibits mitochondrial complex I activity, leading to membrane potential decline and consequently to reduction in H2O2 and NO production rates.”

“ Catechin may increase the capacity of EPCs for the resistance to apoptosis induced by H2O2.”

“ Catechin also reduced injury produced by hydrogen peroxide , 4-hydroxynonenal, rotenone and 6-hydroxydopamine as shown by increases in cellular viability and [3H]DA uptake.”

“ Catechin cytotoxicity toward isolated hepatocytes was also markedly enhanced by hydrogen peroxide or cumene hydroperoxide and was prevented by benzylimidazole, suggesting that catechin could be metabolically activated by P450 peroxidase activity to form cytotoxic quinoid species.”

“Catalase prevented GEC-induced growth inhibition of Actinomyces naeslundii and Streptococcus mutans suggesting that hydrogen peroxide may be involved in the antimicrobial activity of catechins.”