Possible Interaction: Catechin and Glutathione

“Single dose intake of both forms of catechins produced a transient decrease (10‐20%) of plasma ascorbate and total glutathione and an increase of plasma TRAP (16‐19%).”

“Adding glutathione to the detergent-based assay, as used in these studies to measure furin processing activity, strongly reduced inhibition by a number of polyphenols ( catechins , gallic acid and quercetin), while the effect on the genuine inhibitor nona-D-arginine remained unchanged.”

“Some studies have demonstrated that catechins could significantly inhibit the excessive oxidative stress through direct or indirect antioxidant effects and promote the activation of the antioxidative substances such as glutathione peroxidases (GPO) and glutathione (GSH), reducing the oxidative damages to the colon.”

“EGCG and EGC protected the depletion of α-tocopherol in the cells, and the glutathione content was enhanced by all four catechins.”

“Nutrients to increase glutathione levels and activity include lipoic acid, vitamins E and C , and selenium.”

“ CTN significantly increased the antioxidant enzyme activities, total content of reduced glutathione , and reduced the malondialdehyde (MDA) level in rat liver and kidney tissues homogenates, and also corrected the histopathological abnormalities, suggesting its antioxidant potential.”

“Topical treatment with the BCF or CAT formulations (1%) significantly reduced the decrease in GSH levels and decreased myeloperoxidase activity and the secretion of pro-inflammatory cytokines IL-1β and IL-6 induced by UVB radiation (P<0.05), indicating that both BCF and CAT had anti-inflammatory effects.”

“Lophirones B and C attenuated AFB1-mediated decrease in superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and reduced glutathione.”

“A significantly depleted activity of antioxidant enzymes and content of glutathione in MCAO group were protected significantly in MCAO group pretreated with CH.”

“Combined deficiency of C and GSH resulted in the highest macrophage and eosinophil counts of any group.”

“In unexposed animals, the combined deficiency of C and GSH modified the cellular composition of cells recovered in lavage fluid, i.e., the increased number of eosinophils and macrophages in BAL fluid.”

“We conclude that combined deficiency of C and GSH increased susceptibility to inhaled ROFA; caused unusual BAL cellular changes; resulted in lower antioxidant concentrations in BAL than were observed with single deficiencies.”