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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Catechin
supplement:
Epigallocatechin
Research Papers that Mention the Interaction
“EC did not have any effects on cellular accumulation of P‐gp substrates, rhodamine‐123 and daunorubicin, but the other catechins increased the accumulation in the order of EGC ”
Inhibition of P‐glycoprotein function by tea catechins in KB‐C2 cells“Collectively, GTE catechins similarly protect against endotoxin-TLR4-NFκB inflammation in NASH, but EGCG and CAT exert differential prebiotic and antimicrobial activities suggesting that catechin-mediated shifts in microbiota composition are not entirely responsible for their benefits along the gut-liver axis.”
Epigallocatechin gallate but not catechin prevents nonalcoholic steatohepatitis in mice similar to green tea extract while differentially affecting the gut microbiota.“Similarly, the combined treatment with 5 microM EGC and 5 microM of C , EC, EGCG or ECG also reduced the cytotoxicity.”
“The percentage of inhibition of PLA(2) by catechins at 0.6 micromol increased in the order of (-)-epicatechin (23.3%), (+)-catechin (CAT; 24.8%), (-)-epigallocatechin (25.7%), (-)-epicatechin gallate (39.7%) and (-)-epigallocatechin gallate (EGCG; 64.9%).”
“A reduction of the effect on the cell … rate caused by PQ was found when EGCG … CT were added at concentrations of more than 10.0 microM. These concentrations of EGCG and CT alone had no effect on cell cycle rate, which is used as index of cell proliferation.”
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