Possible Interaction: Catechin and Epigallocatechin Gallate

“Thus, GTC intake results in the incorporation of catechin metabolites into human skin associated with abrogated UVR-induced 12-HETE; this may contribute to protection against sunburn inflammation and potentially longer-term UVR-mediated damage.”

“ Catechins , the major components of Gte, showed various inhibitory effects, in which (-)-epigallocatechin-3-gallate ( EGCG ) exhibited a stronger inhibition than any other catechins tested.”

“Addition of EGCG to the sheet culture of MSC markedly increased not only wet weight (A) and sGAG amount (B) but also type II collagen amount ( C ) in the cartilage-like cell sheet.”

“All the catechins alter gA channel function and modify bilayer properties, with a 500‐fold range in potency ( EGCG > ECG ≫ EGC > EC).”

“Subsequently, the use of different catechins showed that the effect of epigallocatechin-3-gallate (EGCG) was stronger than that of other catechins.”

“Compared to control-… cells, treatment with catechin agents significantly suppressed cell growth in a dose-dependent fashion (… < 0.01), with strongest effects evoked by ECG and EGCG in UROtsa cells, ECG in low-grade RT4 and SW780 cells, … PP-60 and EGCG in high-grade TCCSUP and T24 cells.”

“When EGCG was included in the incubation with vitamin E or C , more antioxidant activities were consistently observed than when vitamins were added alone.”

“The amounts of EGCg required to inhibit by both criteria was reduced 10 times by combination with inactive catechins such as (-)-epicatechin (EC), (-)-epigallocatechin (EGC) or (-)-epicatechin-3-gallate (ECG).”

“In human subjects, it has been reported that the bioavailability of EGCg increases after repeated oral catechin intake.”

“SFN and EGCG significantly, but catechin weakly, attenuated the intracellular ROS.”