Possible Interaction: Catechin and Doxorubicin Hydrochloride

“While patients treated on regimens A and B were …% at 5 years, respectively), patients treated on regimen C were at a 16-fold increased risk of developing t-MDS/AML (cumulative incidence: 11% … 90 to 140 g/m2, cyclophosphamide from 9.6 to 17.6 g/m2, and doxorubicin ….”

“These results suggest that mitomycin C could enhance the cardiotoxicity of doxorubicin.”

“In the present study we investigated whether vitamin E and catechin can reduce the toxic effects of doxorubicin.”

“We conclude that vitamin E and catechin significantly reduce doxorubicin-induced hepatotoxicity in rats.”

“Abstract Treatment of P815 tumor cells with adriamycin increased their sensitivity to killing by anti-P815 antibody plus C , but not by allogeneic P815-sensitized spleen cells.”

“Pretreatment of the cells with adriamycin , actinomycin D, and puromycin increased the sensitivity of the cells to killing by rabbit anti-P815 antibody plus guinea pig C , but not by allogeneic P815-sensitized spleen cells.”

“Therefore, CAT could be a promising cytoprotective agent against DOX cardiotoxicity.”

“CHL was effective as an antimutagen against all four antitumor drugs, and CAT was a strong inhibitor of DOX mutagenicity, but had little effect on BL, CP and CISP.”