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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Catechin
drug:
Cyclosporine
Research Papers that Mention the Interaction
“Furthermore, both cyclosporine A (P-glycoprotein inhibitor) and MK-571 (MRP-2 inhibitor) significantly increased the cellular uptake and transport of (+)-catechin and puerarin.”
Absorptive interactions of concurrent oral administration of (+)-catechin and puerarin in rats and the underlying mechanisms“Binding of cyclosporin A to cyclophilins A, B, and C , respectively, results in complexes of significantly different inhibitory potency.”
“Poly I C induced a reduction in maximal mitochondrial respiration of human hepatocytes which was prevented partially by preincubation with cyclosporine A (a mitochondrial permeability transition pore-opening inhibitor).”
“It is also observed that catechin (100 mg/kg/day) along with CsA further increased the catalase levels as compared with CsA alone treated group, but not with lower dose of catechin.”
“… catechin (… CsA for 21 days significantly reduced the lipid peroxidation and restored the decreased glutathione levels as compared with CsA alone group, but lower dose of … of catechin (100 mg/kg/day) along with CsA significantly increased the superoxide dismutase (SOD) levels as compared with CsA alone treated group.”
Attenuation of Cyclosporine-Induced Renal Dysfunction by Catechin: Possible Antioxidant Mechanism
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