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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Castor Oil
drug:
Loperamide
Research Papers that Mention the Interaction
“ Loperamide significantly inhibited the diarrhea induced by 5-HT, castor oil and PGE2.”
Effect of the 5-hydroxytryptamine3 (5-HT3)-receptor antagonist KB-R6933 on experimental diarrhea models.“ Castor oil strongly increased the occurrence of manometrically recorded propulsive giant contractions (500 to 1000% over control values) of transverse and distal colon, this effect being significantly prevented (80 to 100%) by SR 48968 and loperamide and partially by SR 140333 (35% distal colon, 70% transverse colon).”
“Oral treatment with loperamide at 5 mg/kg markedly suppressed diarrhea induced by castor oil and barium chloride.”
“BGH, as well as CSG and LP , significantly inhibited the diarrhea induced by castor oil or BaCl2, but not the diarrhea induced by pilocarpine or serotonin.”
“ Loperamide markedly suppressed the appearance of diarrhea induced by oral administration of castor oil in rats and the ED50 values for 1 and 2 hr protection was 0.082 and 0.42 mg/kg p.o.,”
“ Loperamide (2 mg/kg) and apigenin (2 and 10 mg/kg) inhibited intestinal movement of the charcoal meal and also inhibited castor oil and MgSO4-induced diarrhoea.”
Antidiarrhoeal assessment of hydroalcoholic and hexane extracts of Dracocephalum kotschyi Boiss. and apigenin in mice
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