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Last Updated: 2 years ago

Possible Interaction: Castor Oil and Loperamide


Castor Oil

Research Papers that Mention the Interaction

Loperamide significantly inhibited the diarrhea induced by 5-HT, castor oil and PGE2.
Japanese journal of pharmacology  •  1999  |  View Paper
Castor oil strongly increased the occurrence of manometrically recorded propulsive giant contractions (500 to 1000% over control values) of transverse and distal colon, this effect being significantly prevented (80 to 100%) by SR 48968 and loperamide and partially by SR 140333 (35% distal colon, 70% transverse colon).
British journal of pharmacology  •  1997  |  View Paper
Oral treatment with loperamide at 5 mg/kg markedly suppressed diarrhea induced by castor oil and barium chloride.
Biological & pharmaceutical bulletin  •  1996  |  View Paper
BGH, as well as CSG and LP , significantly inhibited the diarrhea induced by castor oil or BaCl2, but not the diarrhea induced by pilocarpine or serotonin.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica  •  1993  |  View Paper
Loperamide markedly suppressed the appearance of diarrhea induced by oral administration of castor oil in rats and the ED50 values for 1 and 2 hr protection was 0.082 and 0.42 mg/kg p.o.,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica  •  1978  |  View Paper
Loperamide (2 mg/kg) and apigenin (2 and 10 mg/kg) inhibited intestinal movement of the charcoal meal and also inhibited castor oil and MgSO4-induced diarrhoea.
Research in pharmaceutical sciences  •  2016  |  View Paper