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“ HA concentration in the striatal and hypothalamic regions of the rat treated with castor oil for 9 d significantly decreased in comparison with the control group.”
“ HA concentrations in most brain regions decreased in diarrhea induced by a single administration of castor oil.”
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan • 1991 | View Paper
“ Castor oil , senna, sulphosuccinate and bisacodyl, but not mannitol or lactulose, in doses that cause laxation, increased the formation of histamine , 5‐HT and PG‐LM.”