Possible Interaction: Caseins and Progesterone

“At a supraphysiological concentration (10 μg/ml), progesterone inhibited cell growth, alveolar branching morphogenesis, and casein accumulation.”

“ Progesterone (0.01–1 μg/ml) induced cellular proliferation as well as multilobular and lobuloductal branching morphogenesis, and suppressed casein accumulation.”

“ Progesterone inhibits casein gene expression in the mammary gland during pregnancy.”

“The addition of progesterone at concentrations above 10 ng/ml inhibited both the casein and alpha-lactalbumin accumulation that were induced by the synergistic actions of insulin, prolactin and cortisol.”

“The inhibition of the casein accumulation by progesterone was about 80% in the presence of insulin and prolactin, and about 40% in the presence of insulin, prolactin and 1 microgram/ml of cortisol, indicating that cortisol partially antagonized the action of progesterone on the casein synthesis.”

“When the inhibitory effect of progesterone on the accumulation of both alpha-lactalbumin and casein was examined in cultured mammary tissues from virgin, early pregnant, mid-pregnant and late pregnant mice, the degree of inhibition was markedly reduced in tissue from late pregnant mice.”

“Glucocorticoids amplify and progesterone inhibits prolactin action on transcription of casein genes.”

“ Progesterone which is known to prevent the accumulation of casein mRNAs is also a potent inhibitor of casein mRNA translation whereas glucocorticoids exert their effect essentially by favouring the accumulation of casein mRNA but not by modifying their translation efficiency.”

“Conversely, perinatal progesterone treatment inhibited both casein mRNA induction and the formation of lobules.”

“In addition, progesterone inhibited almost completely the formation of membrane-bound polysomes and the anchorage of casein mRNA to endoplasmic reticulum.”

“Further data indicate that two steroid hormones, hydrocortisone and progesterone , were able to modulate the prolactin-induced accumulation of casein mRNA.”

“The induction of casein mRNA by prolactin was inhibited in a dose-dependent manner by the simultaneous addition of progesterone to the organ culture.”

“Thus, hydrocortisone appears to potentiate the prolactin induction of casein mRNA, whereas progesterone is able to prevent casein mRNA accumulation.”

“Daily injections of progesterone (5 mg) increased both the number of rats remaining pregnant and fetal survival rates in those fed sucrose, a protein-free diet or casein.”