Possible Interaction: Caseins and Hydrocortisone

“ Hydrocortisone (0.1–10 μg/ml) induced alveolar and multilobular branching morphogenesis, suppressed lobuloductal branching morphogenesis, and enhanced casein accumulation.”

“ Hydrocortisone at concentrations of 10(-9)-10(-6) M inhibited the secretion of both casein and alpha-lactalbumin into the culture medium.”

“Previous studies of cultured mammary … showed that addition of cortisol at concentrations ranging from 3 X 10(-… 10(-6) M caused progressive increases in casein accumulation but marked decreases in alpha-lactalbumin accumulation in tissue cultured in … and prolactin (Ono, M., and Oka, T. (1980) Cell 19, 473-480).”

“cGMP, whether in combination with spermidine or alone, when added with insulin and hydrocortisone resulted in a 1.3- to 2.3-fold elevation of casein mRNA levels.”

“Further data indicate that two steroid hormones, hydrocortisone and progesterone, were able to modulate the prolactin-induced accumulation of casein mRNA.”

“Thus, hydrocortisone appears to potentiate the prolactin induction of casein mRNA, whereas progesterone is able to prevent casein mRNA accumulation.”

“Transaminase activity increased 6-fold in adrenalectomized rats fed an 18% casein diet and treated with daily injections of hydrocortisone acetate (2.5 mg per 150 g, body wt) for 14 days; histidase and urocanase activities responded much less (3-fold and 2-fold, respectively).”

“In intact rats, tyrosine transaminase shows a synergistic response to casein hydrolysate when it is given concomitantly with a small dose of hydrocortisone ; under these conditions tryptophan pyrrolase is also responsive, but this effect appears to be due to tryptophan stabilization of the enzyme against degradation.”